Monday, April 25, 2011

Olux


Generic Name: clobetasol (Topical application route)


kloe-BAY-ta-sol PROE-pee-oh-nate


Commonly used brand name(s)

In the U.S.


  • Clobevate

  • Clobex

  • Cormax

  • Embeline

  • Embeline E

  • Embeline Scalp Application

  • Olux

  • Olux/Olux-E Complete Pack

  • Olux-E

  • Temovate

  • Temovate E

In Canada


  • Clobetasol Propionate

  • Dermovate

  • Dermovate Scalp Application

  • Med Clobetasol Scalp Application

  • Ratio-Clobetasol

Available Dosage Forms:


  • Cream

  • Ointment

  • Gel/Jelly

  • Spray

  • Solution

  • Foam

  • Emollient Cream

  • Lotion

  • Shampoo

Therapeutic Class: Corticosteroid, Very Strong


Pharmacologic Class: Clobetasol


Uses For Olux


Clobetasol topical is used to help relieve redness, itching, swelling, or other discomfort caused by skin conditions. The solution and foam are used for scalp problems, the lotion and spray are used for moderate to severe plaque psoriasis, and the shampoo is used for moderate to severe scalp psoriasis. This medicine is a corticosteroid (cortisone-like medicine or steroid).


This medicine is available only with your doctor's prescription.


Before Using Olux


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of clobetasol topical gel, foam, cream, ointment, or scalp solution in children 12 years of age and older. However, because of this medicine's toxicity, it should be used with caution. Children may absorb large amounts through the skin, which can cause serious side effects. If your child is using this medicine, follow your doctor's instructions very carefully. Safety and efficacy have not been established in children younger than 12 years of age and the use of clobetasol topical gel, foam, cream, ointment, or scalp solution is not recommended. The safety and efficacy of clobetasol topical spray, lotion, or shampoo have not been established in children and use is not recommended.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of clobetasol topical in the elderly.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.


Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Cushing's syndrome (adrenal gland disorder) or

  • Diabetes or

  • Hyperglycemia (high blood sugar) or

  • Intracranial hypertension (increased pressure in the head)—Use with caution. May make these conditions worse.

  • Infection of the skin at or near the place of application or

  • Large sores, broken skin, or severe skin injury at the place of application—The chance of side effects may be increased.

  • Perioral dermatitis (skin problem) or

  • Rosacea (skin problem)—Should not be used in patients with these conditions.

Proper Use of clobetasol

This section provides information on the proper use of a number of products that contain clobetasol. It may not be specific to Olux. Please read with care.


It is very important that you use this medicine only as directed by your doctor. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may cause unwanted side effects or skin irritation.


This medicine is for use on the skin only. Do not get it in your eyes, nose, mouth, or vagina. Do not use it on skin areas that have cuts, scrapes, or burns. If it does get on these areas, rinse it off right away with water.


This medicine should only be used for skin conditions that your doctor is treating. Check with your doctor before using it for other conditions, especially if you think that a skin infection may be present. This medicine should not be used to treat certain kinds of skin infections or conditions, such as severe burns.


Do not use this medicine on the face, groin, or underarms unless directed to do so by your doctor.


To use the cream, foam, gel, lotion, ointment, or spray:


  • Wash your hands with soap and water before and after using this medicine.

  • Apply a thin layer of this medicine to the affected area of the skin. Rub it in gently.

  • With the lotion, protect the skin from water, clothing, or anything that causes rubbing until the medicine has dried. Also, shake the lotion well before using it.

  • Do not bandage or otherwise wrap the skin being treated unless directed to do so by your doctor.

To use the foam, scalp solution, or shampoo:


  • Wash your hands with soap and water before and after using this medicine.

  • Apply a thin layer of this medicine to the affected area of the scalp. Rub it in gently.

  • Do not cover the scalp (e.g., shower cap, bathing cap) while it is being treated.

  • Do not use the shampoo for more than 4 weeks, the foam and scalp solution for more than 2 weeks unless your doctor has told you to.

This medicine comes with a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For redness, itching, and swelling of the skin:
    • For topical dosage forms (cream, gel, or ointment):
      • Adults—Apply to the affected area of the skin two times per day.

      • Children 12 to 17 years of age—Apply to the affected area of the skin two times per day.

      • Children younger than 12 years of age—Use is not recommended.


    • For topical dosage form (lotion):
      • Adults—Apply to the affected area of the skin two times per day.

      • Children—Use is not recommended.



  • For plaque psoriasis:
    • For topical dosage form (foam):
      • Adults—Apply to the affected area of the skin two times per day, once in the morning and once at night.

      • Children 12 to 17 years of age—Apply to the affected area of the skin two times per day, once in the morning and once at night.

      • Children younger than 12 years of age—Use is not recommended.


    • For topical dosage form (spray):
      • Adults—Spray to the affected area of the skin two times per day.

      • Children—Use is not recommended.



  • For scalp problems:
    • For topical dosage form (foam or scalp solution):
      • Adults—Apply to the affected area of the scalp two times per day, once in the morning and once at night.

      • Children 12 to 17 years of age—Apply to the affected area of the scalp two times per day, once in the morning and once at night.

      • Children younger than 12 years of age—Use is not recommended.


    • For topical dosage form (shampoo):
      • Adults—Apply to the affected area of the scalp once a day.

      • Children—Use is not recommended.



Missed Dose


If you miss a dose of this medicine, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.


Storage


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Store the foam can at room temperature, away from heat and direct light. Do not keep this medicine inside a car where it could be exposed to extreme heat. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.


Precautions While Using Olux


It is very important that your doctor check the progress of you or your child at regular visits for any unwanted effects that may be caused by this medicine.


If your or your child's symptoms do not improve within a few days, or if they become worse, check with your doctor.


Using too much of this medicine or using it for a long time may increase your risk of having adrenal gland problems. The risk is greater for children and patients who use large amounts for a long time. Talk to your doctor right away if you or your child have more than one of these symptoms while you are using this medicine: blurred vision; dizziness or fainting; a fast, irregular, or pounding heartbeat; increased thirst or urination; irritability; or unusual tiredness or weakness.


Stop using this medicine and check with your doctor right away if you or your child have a skin rash, burning, stinging, swelling, or irritation on the skin.


Make sure your doctor knows that you are using clobetasol gel. You may need to stop using this medicine several days before having surgery.


Do not use cosmetics or other skin care products on the treated areas.


Olux Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


More common
  • Burning or stinging at the application site

Less common
  • Burning sensation of the skin

  • dry skin

  • flushing or redness of the skin

  • itching, scaling, severe redness, soreness, or swelling of the skin

  • skin irritation

  • skin rash, encrusted, scaly and oozing

  • thinning of the skin with easy bruising, especially when used on the face or where the skin folds together (e.g. between the fingers)

Incidence not known
  • Burning, itching, and pain in hairy areas, or pus at the root of the hair

  • hair loss

  • redness and scaling around the mouth

  • thinning of the hair

  • thinning, weakness, or wasting away of the skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Cough

  • sore throat

Less common
  • Burning, itching, and pain in hairy areas, or pus at the root of the hair

  • changes in skin coloring

  • body aches or pain

  • congestion

  • cough

  • dryness or soreness of the throat

  • fever

  • headache

  • hoarseness

  • raised, dark red, wart-like spots on the skin, especially when used on the face

  • skin discomfort

  • stuffy or runny nose

  • tender, swollen glands in the neck

  • trouble with swallowing

  • unusual tiredness or weakness

  • voice changes

Incidence not known
  • Acne or pimples

  • burning and itching of the skin with pinhead-sized red blisters

  • increased hair growth on the forehead, back, arms, and legs

  • lightening of normal skin color

  • lightening of treated areas of dark skin

  • reddish purple lines on the arms, face, legs, trunk, or groin

  • softening of the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Olux side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Olux resources


  • Olux Side Effects (in more detail)
  • Olux Use in Pregnancy & Breastfeeding
  • Olux Drug Interactions
  • Olux Support Group
  • 7 Reviews for Olux - Add your own review/rating


  • Olux Prescribing Information (FDA)

  • Olux Foam MedFacts Consumer Leaflet (Wolters Kluwer)

  • Olux Concise Consumer Information (Cerner Multum)

  • Clobex Lotion MedFacts Consumer Leaflet (Wolters Kluwer)

  • Clobex Prescribing Information (FDA)

  • Cormax Prescribing Information (FDA)

  • Embeline Cream MedFacts Consumer Leaflet (Wolters Kluwer)

  • Olux-E Emollient Foam MedFacts Consumer Leaflet (Wolters Kluwer)

  • Olux-E Prescribing Information (FDA)

  • Temovate Prescribing Information (FDA)



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Friday, April 15, 2011

Brompheniramine/Dextromethorphan/Guaifenesin


Pronunciation: brome-fen-EER-a-meen/dex-troe-meth-OR-fan/gwye-FEN-e-sin
Generic Name: Brompheniramine/Dextromethorphan/Guaifenesin
Brand Name: Tusnel


Brompheniramine/Dextromethorphan/Guaifenesin is used for:

Relieving runny nose, sneezing, cough, and throat and airway irritation due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.


Brompheniramine/Dextromethorphan/Guaifenesin is an antihistamine, cough suppressant, and expectorant combination. The expectorant works by loosening mucus and lung secretions in the chest, and making coughs more productive. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing while the cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.


Do NOT use Brompheniramine/Dextromethorphan/Guaifenesin if:


  • you are allergic to any ingredient in Brompheniramine/Dextromethorphan/Guaifenesin

  • you have severe high blood pressure, severe heart blood vessel disease, rapid heartbeat, or severe heart problems

  • you are unable to urinate or are having an asthma attack

  • you are taking sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.



Before using Brompheniramine/Dextromethorphan/Guaifenesin:


Some medical conditions may interact with Brompheniramine/Dextromethorphan/Guaifenesin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:


  • if you are pregnant, planning to become pregnant, or are breast-feeding

  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

  • if you have allergies to medicines, foods, or other substances

  • if you have a fast, slow, or irregular heartbeat

  • if you have a history of adrenal gland problems (eg, adrenal gland tumor), heart problems, high blood pressure, diabetes, heart blood vessel problems, stroke, glaucoma, a blockage of your bladder, stomach, or intestines, ulcers, trouble urinating, an enlarged prostate, seizures, or an overactive thyroid

  • if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Brompheniramine/Dextromethorphan/Guaifenesin. Tell your health care provider if you are taking any other medicines, especially any of the following:


  • Furazolidone, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Brompheniramine/Dextromethorphan/Guaifenesin may be increased

  • Hydantoins (eg, phenytoin) because their side effects may be increased by Brompheniramine/Dextromethorphan/Guaifenesin

This may not be a complete list of all interactions that may occur. Ask your health care provider if Brompheniramine/Dextromethorphan/Guaifenesin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.


How to use Brompheniramine/Dextromethorphan/Guaifenesin:


Use Brompheniramine/Dextromethorphan/Guaifenesin as directed by your doctor. Check the label on the medicine for exact dosing instructions.


  • Brompheniramine/Dextromethorphan/Guaifenesin may be taken with or without food.

  • If you miss a dose of Brompheniramine/Dextromethorphan/Guaifenesin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Brompheniramine/Dextromethorphan/Guaifenesin.



Important safety information:


  • Brompheniramine/Dextromethorphan/Guaifenesin may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Brompheniramine/Dextromethorphan/Guaifenesin. Using Brompheniramine/Dextromethorphan/Guaifenesin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

  • Do not take diet or appetite control medicines while you are taking Brompheniramine/Dextromethorphan/Guaifenesin without checking with your doctor.

  • Brompheniramine/Dextromethorphan/Guaifenesin contains brompheniramine and dextromethorphan. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains brompheniramine or dextromethorphan. If it does or if you are uncertain, contact your doctor or pharmacist.

  • Do NOT exceed the recommended dose or take Brompheniramine/Dextromethorphan/Guaifenesin for longer than prescribed without checking with your doctor.

  • If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.

  • Brompheniramine/Dextromethorphan/Guaifenesin may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Brompheniramine/Dextromethorphan/Guaifenesin. Use a sunscreen or protective clothing if you must be outside for a prolonged period.

  • If you are scheduled for allergy skin testing, do not take Brompheniramine/Dextromethorphan/Guaifenesin for several days before the test because it may decrease your response to the skin tests.

  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Brompheniramine/Dextromethorphan/Guaifenesin.

  • Use Brompheniramine/Dextromethorphan/Guaifenesin with caution in the ELDERLY because they may be more sensitive to its effects.

  • Caution is advised when using Brompheniramine/Dextromethorphan/Guaifenesin in CHILDREN because they may be more sensitive to its effects.

  • PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Brompheniramine/Dextromethorphan/Guaifenesin, discuss with your doctor the benefits and risks of using Brompheniramine/Dextromethorphan/Guaifenesin during pregnancy. It is unknown if Brompheniramine/Dextromethorphan/Guaifenesin is excreted in breast milk. Do not breast-feed while taking Brompheniramine/Dextromethorphan/Guaifenesin.


Possible side effects of Brompheniramine/Dextromethorphan/Guaifenesin:


All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:



Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.



Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.



This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.


See also: Brompheniramine/Dextromethorphan/Guaifenesin side effects (in more detail)


If OVERDOSE is suspected:


Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.


Proper storage of Brompheniramine/Dextromethorphan/Guaifenesin:

Store Brompheniramine/Dextromethorphan/Guaifenesin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Brompheniramine/Dextromethorphan/Guaifenesin out of the reach of children and away from pets.


General information:


  • If you have any questions about Brompheniramine/Dextromethorphan/Guaifenesin, please talk with your doctor, pharmacist, or other health care provider.

  • Brompheniramine/Dextromethorphan/Guaifenesin is to be used only by the patient for whom it is prescribed. Do not share it with other people.

  • If your symptoms do not improve or if they become worse, check with your doctor.

  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Brompheniramine/Dextromethorphan/Guaifenesin. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.



Issue Date: February 1, 2012

Database Edition 12.1.1.002

Copyright © 2012 Wolters Kluwer Health, Inc.

More Brompheniramine/Dextromethorphan/Guaifenesin resources


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